Table 3.
Cumulative incidence of diabetes-related complications and adverse events of base-case analysis
| Cumulative incidence diabetes-related complications (%) |
|||
|---|---|---|---|
| Complication | Lispro | Regular insulin | Difference |
| Background diabetic retinopathy | 83.16 (1.50) | 83.92 (1.42) | −0.76 |
| Proliferative diabetic retinopathy | 32.11 (1.49) | 33.28 (1.46) | −1.17 |
| Macular oedema | 39.67 (1.57) | 40.10 (1.53) | −0.43 |
| Severe vision loss | 25.30 (1.35) | 25.76 (1.34) | −0.46 |
| Cataract | 12.11 (1.02) | 12.00 (1.02) | 0.11 |
| Microalbuminuria | 75.50 (1.91) | 75.83 (2.05) | −0.33 |
| Gross proteinuria | 67.67 (1.76) | 68.45 (1.91) | −0.78 |
| End-stage renal disease | 30.76 (1.61) | 30.95 (1.62) | −0.19 |
| Nephropathy-related death | 28.48 (1.48) | 28.64 (1.46) | −0.16 |
| Ulcer | 47.12 (1.57) | 47.19 (1.55) | −0.07 |
| Recurrent ulcer | 65.37 (4.29) | 66.01 (4.46) | −0.64 |
| Amputation | 14.25 (1.33) | 14.35 (1.23) | −0.1 |
| Recurrent amputation | 7.09 (1.17) | 7.03 (1.04) | 0.06 |
| Neuropathy | 89.30 (1.03) | 89.52 (1.02) | −0.22 |
| Coronary heart failure death | 9.99 (0.97) | 9.80 (0.92) | 0.19 |
| Coronary heart failure event | 23.84 (1.46) | 23.65 (1.33) | 0.19 |
| Peripheral vascular disease | 15.90 (1.08) | 16.31 (1.14) | −0.41 |
| Angina | 8.61 (0.91) | 8.40 (0.87) | 0.21 |
| Stroke death | 3.82 (0.63) | 3.85 (0.63) | −0.03 |
| Stroke event | 8.20 (0.89) | 8.14 (0.86) | 0.06 |
| Myocardial infarction death | 20.00 (1.29) | 20.18 (1.28) | −0.18 |
| Myocardial infarction event | 31.70 (1.45) | 32.09 (1.47) | −0.39 |
| Severe hypoglycaemia | 7.59 (0.18) | 14.20 (0.32) | −6.61 |
Incidence expressed as a mean percentage with standard deviation in parentheses.