Table 1.
Genotype frequencies of the OMI/HTRA2 missense variants A141S and G399S in Swedish AD and PD patients compared to controls
| Variant | Genotype frequency [% (n)] | Patients (n) | χ2 [OR (95% CI)] | P value | ||
|---|---|---|---|---|---|---|
| AD | ||||||
| A141S | GG | GT | TT | Total | χ2 | P |
| Control 1 | 95.6 (305) | 4.4 (14) | 0 (0) | 319 | 1.96 | 0.0453 |
| AD | 91.7 (289) | 8.3 (26) | 0 (0) | 315 | (1.003 to 3.828) | |
| G399S | GG | GA | AA | Total | χ2 | P |
| Control 1 | 100 (318) | 0 (0) | 0 (0) | 318 | NA | NA |
| AD | 100 (304) | 0 (0) | 0 (0) | 304 | ||
| PD | ||||||
| A141S | GG | GT | TT | Total | χ2 | P |
| Control 2 | 94.3 (280) | 5.7 (17) | 0 (0) | 297 | 0.8111 | 0.5793 |
| PD | 95.3 (264) | 4.7 (13) | 0 (0) | 277 | (0.3863 to 1.703) | |
| G399S | GG | GA | AA | Total | χ2 | P |
| Control 2 | 99.0 (298) | 1.0 (3) | 0 (0) | 301 | 0.3625 | 0.3625 |
| PD | 99.6 (274) | 0.4 (1) | 0 (0) | 275 | (0.0375 to 3.508) | |
The two control materials, control 1 and control 2, were age-matched to the AD and PD materials, respectively. A141S (TT) and G399S (AA) were not detected in the materials, and hence, they were excluded from the statistical analysis. OR, odds ratio; CI, confidence interval; NA, not applicable.