Fig. 5.

FVB/J fostered Npy1r^rfb mice and C57BL/6J mice of either genotype showed lower growth rate (A), decreased leptin serum levels (B), and lower weight of visceral (mesenteric + perirenal + retroperitoneal), s.c. (inguinal + dorso-scapular), and epididymal white adipose tissue (WAT) (C) compared with FVB/J-fostered Npy1r^2lox mice. No significant differences were found for the daily food intake (C). Data are the mean ± SEM. Growth rate: Three-way ANOVA for repeated measurements revealed a significant effect of genotype [F_(1,57) = 4.4, P < 0.05], foster mother strain [F_(1,57) = 21.3, P < 0.001], and postnatal days– foster mother strain interaction [F_{(12, 684)} = 10.8, P < 0.001]; n = 13–16 from eight to nine litters. Leptin serum levels: Two-way ANOVA revealed a significant effect of foster mother strain [F_(1,31) = 5.52, P < 0.05]; n = 7–13 from two litters. WAT weight: Two-ways ANOVA revealed a significant effect of foster mother strain, genotype, and their interaction [visceral WAT: F_(1,13) = 10.0, 18.0, and 15.8, s.c. WAT: F_(1,13) = 13.1, 13.0, and 14.2, epididymal WAT: F_(1,13) = 8.1, 9.3, and 12.3, respectively; P < 0.01]; n = 4–7 from two litters. *P < 0.01 and ^#P < 0.05 versus Npy1r^2lox fostered to FVB/J by Newman–Keuls test.