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. 2011 Nov 14;108(48):19407–19412. doi: 10.1073/pnas.1112052108

Fig. 5.

Fig. 5.

Blockade of NR2B prevents reinstated heroin seeking. (A) The reinstatement of lever pressing by heroin or a light/tone cue previously associated with heroin infusion was reduced by pretreatment with Ifen (3.0 mg/kg, i.p.). (B) Ifen (8 ρmol) administration into the NAcore prevented heroin- or cue-induced reinstatement of active lever pressing. *P < 0.01, compared with exctinction lever pressing, #P < 0.01, compared with heroin or cue induced levels of pressing using Bonferroni post hoc. (C) Treatment with siRNA directed against NR2A or NR2B significantly lowered the content of the targeted protein (*P < 0.05, comparing siRNA NR2A to siRNA NR2B), but only treatment with NR2B siRNA significantly reduced cue- or heroin- induced reinstatement comparing with NR2A siRNA (*P < 0.01, compared with exctinction lever pressing, #P < 0.01, comparing siRNA NR2A to siRNA2B using Bonferroni post hoc.).