Table 1.
Hematological analysis and serum biochemical parameters from Swiss albino mice 168 h after a single i.v. dose
| Saline | Paclitaxel, 10 mg/kg | Nanoburrs, 35 mg/kg | |
| RBC, M/μL | 8.09 ± 0.676 | 8.30 ± 0.598 | 7.94 ± 0.512 |
| HGB, g/dL | 13.7 ± 1.11 | 14.2 ± 0.796 | 13.5 ± 0.685 |
| HCT, % | 49.0 ± 3.19 | 49.3 ± 2.63 | 46.9 ± 1.78 |
| MCV, fL | 60.6 ± 1.95 | 59.5 ± 1.55 | 59.2 ± 2.51 |
| MCH, pg | 16.8 ± 0.386 | 17.1 ± 0.679 | 17.0 ± 0.629 |
| MCHC, g/dL | 27.9 ± 0.592 | 28.8 ± 0.750 | 28.7 ± 0.882 |
| PLT, K/μL | 1395 ± 42.1 | 1026 ± 533 | 1415 ± 514 |
| WBC, K/μL | 2.03 ± 0.677 | 2.05 ± 0.454 | 3.79 ± 0.741 |
| Neut, % | 0.28 ± 0.167 | 0.231 ± 0.227 | 0.278 ± 0.185 |
| Lymph, % | 86.8 ± 17.2 | 68.9 ± 12.9 | 77.4 ± 15.6 |
| Mono, % | 3.70 ± 4.70 | 16.7 ± 6.38 | 11.4 ± 7.15 |
| Eo, % | 0.185 ± 0.230 | 0.226 ± 0.427 | 0.124 ± 0.146 |
| Baso, % | 9.03 ± 12.5 | 14.0 ± 7.77 | 10.78 ± 8.90 |
| ALP, U/L | 39.8 ± 3.24 | 41.7 ± 1.77 | 43.6 ± 2.73 |
| AST, U/L | 109.50 ± 11.22 | 119.83 ± 8.23 | 114.67 ± 12.51 |
| ALT, U/L | 65.23 ± 10.40 | 61.01 ± 6.10 | 66.10 ± 4.47 |
| BUN, mmol/L | 8.40 ± 1.48 | 8.31 ± 1.61 | 7.98 ± 1.55 |
Results are expressed as mean ± SD, n = 6. Units of mg/kg represent the active drug composition. RBC, red blood cells; HGB, hemoglobin; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; PLT, platelets; WBC, white blood cells; Neut, neutrophils; Lymph, lymphocytes; Mono, monocytes; Eos, eosinophils; Baso, basophils; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urea nitrogen.