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. 2011 Nov 14;108(48):19270–19275. doi: 10.1073/pnas.1112801108

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Fig. 4. — Arrest of molar tooth development associated with a lack of Bmp4 transcription in Barx1/Msx1 compound mutants. Frontal sections through upper (A, C, E, G, I, K, M, O, Q, and S) and lower (B, D, F, H, J, L, N, P, R, and T) developing first molars at E14.5 (A, B, E, F, I, J, M, N, Q, and R) and E16.5 (C, D, G, H, K, L, O, P, S, and T). Hematoxylin and eosin stained sections of Barx1^+/−; Msx1^+/− (A–D), Barx1^+/+; Msx1^−/− (E–H), and Barx1^−/−; Msx1^+/− (I–L). (M–T) Expression of BMP4 in the condensed mesenchyme of first molar tooth germs of Barx1^+/−; Msx1^+/− (M–P) and Barx1^−/−; Msx1^+/− (Q–T). Permanent arrest of molar tooth development was observed in three separate Barx1^−/−; Msx1^+/− animals and was highly penetrant. At E16.5, one molar tooth germ (n = 1/12) was occasionally observed at the cap stage (corresponding to E14.5).