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. 2011 Oct 7;118(22):5832–5839. doi: 10.1182/blood-2011-05-353961

Figure 3.

Figure 3

TACI is required for differentiation of B cells into ASCs. TACI-ko animals had decreased NP-specific IgM ASCs or NP-specific IgG ASCs compared with wild-type. ASCs were enumerated in B cells isolated from the spleen (A-B) or in bone marrow cell suspensions (C-D) of C57BL/6-wt or C57BL/6-TACI-ko 21 days after immunization, by ELISPOT. Below the graphs, the diagrams show the ELISPOT wells from which the ASCs were enumerated and plated with 106, 5 × 105, or 105 cells, as indicated. Values were compared by t test. Significant differences: *P < .05; **P < .01. Data resulted from the analyses of 5 wild-type mice and 4 TACI-ko mice.