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. 2011 Sep 13;118(22):5965–5976. doi: 10.1182/blood-2011-07-367011

Figure 3.

Figure 3

TMH60 mediate GVL against mCP-CML. B6.H60 mice were irradiated and reconstituted with C3H.SW BM, B6.H60 mCP-CML cells with no T cells or with 2 × 104 or 4 × 104 CD8+CD44+ TM from DEC-H60–vaccinated or unmanipulated C3H.SW mice. (A) Survival. All deaths were from leukemia. P < .0003 comparing either TMH60 recipient group with its TM control; P ≤ .0002 comparing any TM recipient group with the BM alone control. (B) Numbers of NGFR+ cells in peripheral blood. (C) Representative flow cytometry of TetH60+ cells in peripheral blood at day 7, gated on CD8+ cells. (D) Number of TetH60+ cells in blood of TMH60 recipients at days +7, +14, +21, +27, and +33.