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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Ann Neurol. 2010 Nov 8;69(2):320–327. doi: 10.1002/ana.22112

Figure.

Figure

Immunostaining of CAA showing increasing severity of CAA. All panels are shown in original magnification ×200. (A) Mild severity (grade 1) showing incomplete circumferential staining of leptomeningeal blood vessels in a case with sparse positivity. (B) Moderate severity (grade 2) showing strong circumferential staining of leptomeningeal blood vessels. (C) Severe (grade 3) with multiple blood vessels with strong circumferential staining in a case with widespread positivity. (D) Very severe (grade 4) with amyloid positivity emanating from the blood vessels into surrounding neuropil, in a case with widespread circumferential staining. CAA = cerebral amyloid angiopathy.