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. 2011 Dec;80(6):1076–1084. doi: 10.1124/mol.111.073585

Fig. 1.

Fig. 1.

Reduction of sGC expression in human glioma tissues and cell lines. sGC expression in glioma cell lines (U87, U251, U373, A172, LN18, LN229, and D54) was examined by Western blot (A) and real time-Q-PCR (B) and compared with that in BE2 human neuroblastoma cell line, which normally expresses both sGC α1 and β1 subunits at levels similar to those in normal human cortex (D) (Bonkale et al., 1995; Corbalán et al., 2002; Sharina et al., 2008). The GEO database analysis of sGC gene expression in human glioma tissues of different grade (C) showed that the expression of sGC α1 and β1 is markedly decreased in astrocytoma (n = 26), oligodendrocytoma (n = 50), and glioblastoma multiforme (n = 81) compared with normal brain tissues (n = 23). Data are mean ± S.E.M. n = 3 to 6 per group for glioma cell lines. **, P < 0.01 (versus normal brain tissues).