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. 2011 Feb 9;12:50. doi: 10.1186/1471-2105-12-50

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Copyright ©2011 Sugaya and Furuya; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Screenshots of Dr. PIAS. (A) Top page of Dr. PIAS. (B) 'Advanced search' form. (C) Main search result summarizing PPIs and their druggability scores. (D) PPI network derived from a search result of Dr. PIAS. The network is drawn using the software eXpanda [48]. (E) Example of potential ligand-binding pocket on a PPI interface, which was used for assessing the druggability of a PPI. The pocket is shown by atoms colored red. The image is generated using the software Jmol [49]. (To see the pocket information, click the header 'structural information' in the main search result table, then click the header '# protein complexes in PDB' in the 'Structural information' table in a new window/tab opened, and then click '[pocket]' after the list of PDB entry names in the 'PDB information' table in a new window/tab opened.)