Table 3.

Information stored in Dr. PIAS.

Information	Source(s) or program(s) used
Structural information
Tertiary structures	[22-24]
Pockets on PPI interface	[25]
Volume	[6,25]
Accessible surface area	[6,25]
Compactness	[6]
Planarity	[6]
Narrowness	[6]
Curvature	[26]
Roughness	[26]
Amino acid composition	[6,24,25,27]
Domains	[28,29]
Disordered regions	[37]
Amino acid sequence motifs	[38,39]
Drug/chemical information
FDA-approved drugs	[40]
Chemicals associated with interacting proteins	[41]
Functional information
Human diseases in OMIM	[42]
Number of interacting proteins in PPI network	[6]
Biological pathways	[43,44]
GO terms and identity scores of GO terms	[6,45]
Gene expression profiles and similarity scores of profiles	[6,46]
Paralogs	[43,47]