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Maternal methadone dose and breastmilk methadone concentrations. Boxes represent interquartile range (IQR) of observed values with the median value represented with a contrasting line within the box. The whiskers represent adjacent values, defined as the value closest to (75% value + 3/2[IQR]) and whose absolute value is less than the cut-point for the adjacent value. Markers outside the whiskers represent any values outside of the adjacent values.38
