Table 1.

Parameter values used to generate random numbers in computer simulations of a force response due to myosin crossbridges subjected to sinusoidal length perturbations, and estimated parameter values from that force response fit to (15). For all simulations ${\bar{t}}_{\det }=96\hspace{0.17em}ms$, N = 20,000 and k_stiff = 1 pN/nm. Est[] = estimated value of bracketed parameter, () indicates the ±95% confidence intervals for estimated value. The correlation between actual and estimated values resulted in a correlation coefficient greater than 0.997 for each parameter.

Sim number	p	β (ms)	${\bar{t}}_{\text{att}}$ (ms)	ξ (pN/nm)	Est[p]	Est[β] (ms)	Est[${\bar{t}}_{\text{att}}$] (ms)	Est[ξ] (pN/nm)
(1)	1	24	24	4000	0.91 (0.01)	25.13 (0.06)	22.89	4005.0 (0.5)
(2)	2	12	24	4000	2.01 (0.01)	11.98 (0.03)	24.09	4019.8 (0.4)
(3)	3	8	24	4000	3.22 (0.01)	7.48 (0.02)	24.08	3981.2 (0.4)
(4)	6	4	24	4000	6.11 (0.02)	3.89 (0.01)	23.79	3986.4 (0.4)
(5)	8	3	24	4000	8.70 (0.03)	2.75 (0.01)	23.95	3997.4 (0.4)
(6)	4	24	96	10000	3.99 (0.01)	24.03 (0.03)	95.88	10007.0 (0.3)
(7)	8	12	96	10000	6.83 (0.01)	13.93 (0.02)	95.12	10003.8 (0.3)
(8)	12	8	96	10000	12.00 (0.02)	7.98 (0.01)	95.71	10012.8 (0.3)
(9)	16	6	96	10000	16.04 (0.03)	6.05 (0.01)	97.03	10022.6 (0.3)
(10)	24	4	96	10000	24.10 (0.06)	3.99 (0.01)	96.07	10017.2 (0.3)
(11)	48	2	96	10000	49.61 (0.15)	1.92 (0.01)	95.13	10004.0 (0.3)

Note: $\xi =N({\bar{t}}_{\text{att}}/{\bar{t}}_{\mathrm{cycle}}){\bar{k}}_{\text{stiff}}$.