(A–F) Localization of Fim1p-GFP during mating
(A), sporulation (B and D), and spore germination (F). (C and E) DIC
images of the cells shown in B and D, respectively.
fim1+-GFP strains JW109 and
JW117 were crossed on an SPA plate at 25°C, and samples taken after
12 h (A), 24 h (B and C), and 50 h (D and E) were
examined after resuspension in liquid SPA medium. After 60 h, the
mature asci were digested with Glusulase (NEN, Boston, MA) to release
spores, which were then incubated in liquid EMM medium at 25°C and
examined after 12 h (F). (G) Defective sporulation in
fim1 deletion cells.
fim1-Δ1 strains JW144 and JW142 were
crossed on an SPA plate at 25°C and examined by DIC after 50 h.
Bar, 10 μm.