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. 2011 Dec 1;6(12):e28355. doi: 10.1371/journal.pone.0028355

Figure 2. Elevated basal corticosterone levels in young adult Prop1 deficient mice become higher in response to restraint stress.

Figure 2

RIA analysis of circulating corticosterone was carried out on serum from 8 to 10 week males (A) and females (B) of segregating the Prop1 null allele at N4 B6 prior to (white bars) and following restraint stress (black bars). Male Prop1 -/- (n = 6) had significantly elevated basal and post-stress levels of corticosterone compared to Prop1+/− (n = 7) and Prop1+/+ (n = 3). Values represent the mean corticosterone (ng/mL of blood) ± SE. *, P<0.0001. Female Prop1-/- (n = 3) mice had both elevated basal and post-stress levels of corticosterone compared to Prop1+/− (n = 5) and Prop1+/+ (n = 6). Values represent the mean corticosterone (ng/mL of blood) ± SE. *, P<0.005.