F
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The set of pairs which have for at least one epitope i, then a vaccinated host of type h who has virus type v, such that , is successfully vaccinated, i.e. they restrict at least one epitope they are vaccinated against and that epitope has no escape mutations. By contrast, a vaccinated host with is unsuccessfully vaccinated and has the same properties as an unvaccinated infected host. |
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The unit vector of length n that has ith coordinate equal to 1, e.g.
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The Kronecker delta:
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The basic reproductive number. The expected number of secondary cases caused by one primary case in a wholly susceptible population. In this model framework . |
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The control reproductive number. The expected number of secondary cases caused by one primary case in a wholly uninfected population under a control strategy. |
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Lifetime transmission potential of a successfully vaccinated host. In this model framework . |
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Lifetime transmission potential of an unvaccinated or unsuccessfully vaccinated host. . |
K
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The next generation matrix |