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. 2011 Dec 1;7(12):e1002256. doi: 10.1371/journal.pcbi.1002256

Figure 3. Examples of positive regions.

Figure 3

Muscle TFBS hits (threshold of 80%) and the phastCons conservation profile for the region are shown as well. When square brackets are shown, they indicate the original CRM prediction. a) Positive sequence from the muscle set. The muscle-specific TFBS are located in regions of high sequence conservation. b) Positive sequence from the non-muscle. This sequence showed the most consistent increase in reporter expression, with all 12 replicates determined as significantly up-regulated in muscle. c) Positive sequence from the background set. Despite the clear cluster of muscle-specific TFBS located in the region of high sequence conservation, none of the CRM prediction tools could classify this as a muscle CRM.