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. 2011 Dec 1;7(12):e1002395. doi: 10.1371/journal.pgen.1002395

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Wilson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The distribution of fitness effects of (A) new non-synonymous mutations and (B) amino acid substitutions in D. melanogaster (left bars) and D. simulans (right bars). The height of the bar represents the estimated frequency of each selection coefficient aggregated across codons, with the 95% credible interval indicated by a vertical line. In (A) and (B) the bars are colored according to their selection coefficient, with colors closer to red representing increasingly deleterious variants, white representing neutral variants, and colors closer to blue representing increasingly beneficial variants.