Figure 2. Many proteins that lack RNA–binding domains associate specifically with small numbers of mRNAs.

Box plots of the distribution of enrichments for 12 RIp-chip experiments. The y axis shows normalised log₁₀ enrichment ratios in the corresponding RIp-chip experiments (see Figure 1 for details). For each protein, a representative experiment is presented. Black circles show the mRNA encoded by the bait protein used for the RIp-chip experiment, and grey circles other mRNAs that were consistently enriched in independent biological experiments. White circles represent mRNAs not considered significant, either because they are common contaminants in multiple RIp-chip experiments, or because they were not reproducibly enriched in independent replicas of the experiment. The dashed line at two standard deviations above the mean shows the threshold used to define mRNA enrichment.