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. 2011 Dec 1;7(12):e1002396. doi: 10.1371/journal.pgen.1002396

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Walko et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Toluidine blue dye penetration assays. Note localized breaches (arrowheads) of the skin barrier in 1-day-old Plec ^Ogna/+ and Plec ^Ogna/Ogna mice, not noticeable in Plec ^+/+ littermates. (B) Epidermal detachment after tape stripping. Epidermal exfoliation was visible after 6 consecutive tape strippings of 1-day-old Plec ^Ogna/+ mice using D-Squame disks (CuDerm corporation, Dallas, TX) (arrow), whereas for Plec ^Ogna/Ogna mice, 2–3 tape strippings were usually enough for epidermal detachment (arrow). Brackets mark areas to which tape stripping was applied. (C) Transepidermal water loss (TEWL) after 6 consecutive tape strippings was strongly increased in 1-day-old Plec ^Ogna/+ mice, compared to their Plec ^+/+ littermates. Data are shown as mean values ±95% CI (n = 6). *** P<0.001 (two-way ANOVA with Bonferroni post test).