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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Biotechnol Bioeng. 2011 Aug 31;109(2):583–594. doi: 10.1002/bit.23302

Fig. 2.

Fig. 2

ESC-derived EC gene response after exposure to shear stress (5 dyn/cm2 for 8h). Relative gene expression (gene/GAPDH) was measured by qPCR and normalized to its own static control case. mRNA level of endothelial cells markers: vWF, PECAM-1, and VE-cadherin were significantly enhanced (A). From the tight junction group, the mRNA levels of ZO-1 and CLD5 were significantly upreguated; no significant change in expression of OCLD was observed (B). Shear stress significantly modulated the expression of vasoregulatory genes. The mRNA expression of eNOS and COX2 were significantly increased, while the expression of ET-1 was significantly decreased (C). *P < 0.05 compared to unsheared control (n = 3–7).