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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: Int J Cancer. 2011 Aug 26;130(6):1459–1469. doi: 10.1002/ijc.26152

Table 1. The effect of LLL12 on the activity of human protein kinases.

The IC50 inhibitory values of LLL12 on the kinase activity were determined using 10 different concentrations of LLL12 with 100 μM as the highest concentration in kinase assays. Results suggested LLL12 had little or much less effect on other human kinase proteins than STAT3. Staurosporine was used as positive control on these kinase assay (IC50 between <0.001 and 0.456 μM).

Protein Kinases IC50 (μM) Protein Kinases IC50 (μM) Protein Kinases IC50 (μM)
Tyrosine kinases contain SH2 Domain BMX >100 Fgr 57.19 LcK >100
BRK >100 Fyn >100 Lyn >100
CSK 73.92 JAK3 89.70 ZAP-70 >100
Other human protein kinases AKT2 91.76 IKKb >100 PAK2 >100
CDK1/CyclinB >100 JNK1 >100 PDGFR-a >100
FAK >100 JNK2 >100 PKC-a >100
FGFR2 >100 PAK1 >100 PKC-d >100