. Author manuscript; available in PMC: 2013 Mar 15.

Published in final edited form as: Int J Cancer. 2011 Aug 26;130(6):1459–1469. doi: 10.1002/ijc.26152

Table 1. The effect of LLL12 on the activity of human protein kinases.

The IC50 inhibitory values of LLL12 on the kinase activity were determined using 10 different concentrations of LLL12 with 100 μM as the highest concentration in kinase assays. Results suggested LLL12 had little or much less effect on other human kinase proteins than STAT3. Staurosporine was used as positive control on these kinase assay (IC50 between <0.001 and 0.456 μM).

	Protein Kinases	IC₅₀ (μM)	Protein Kinases	IC₅₀ (μM)	Protein Kinases	IC₅₀ (μM)
Tyrosine kinases contain SH2 Domain	BMX	>100	Fgr	57.19	LcK	>100
	BRK	>100	Fyn	>100	Lyn	>100
	CSK	73.92	JAK3	89.70	ZAP-70	>100
Other human protein kinases	AKT2	91.76	IKKb	>100	PAK2	>100
	CDK1/CyclinB	>100	JNK1	>100	PDGFR-a	>100
	FAK	>100	JNK2	>100	PKC-a	>100
	FGFR2	>100	PAK1	>100	PKC-d	>100