Figure 2. Downregulation of activated Src correlates with growth inhibition.
(A) Dasatinib treatment (100 nM) leads to suppression of Src kinase autophosphorylation in cells expressing ZMYM2-FGFR1, CEP110-FGFR1 and BCR-FGFR1. (B) Flow cytometric tracking of cell division with CellTrace™ Violet shows that 72 hours exposure to Dasatinib reduces cell proliferation in cells expressing ZMYM2-FGFR1 but not cells carrying the empty MIEG3 vector or treated with DMSO (vehicle).