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. 2011 Dec;179(6):2709–2719. doi: 10.1016/j.ajpath.2011.08.029

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© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

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PROK1 mediates LPS-induced expression of inflammatory mediators in myometrium. Term myometrium was infected with lentivirus containing miRNA constructs targeting PROK1 or scrambled sequence. Infected explants were subsequently treated with 100 ng/mL of LPS for 24 hours. The expression of IL-1β (A), CCL3 (B), CSF3 (C), and CCL20 (D) in response to 100 ng/mL of LPS was significantly decreased by PROK1 miRNA constructs compared with the scrambled sequence. However, PROK1 suppression did not reduce the effect of LPS on PTGS2 expression (E). LPS treatment had no effect on PTGS1 expression, and this remained unaffected when PROK1 was suppressed (F). *P < 0.05. n/s, not significant (n = 8). Results are presented as mean ± SEM.