Fig. 1.

Workflow of our transcriptional genomics approach. RNA and nuclear proteins were isolated from LV tissue. The RNA was used in microarray analysis followed by TFBS analysis of differentially expressed genes. Nuclear protein extracts were used for protein/DNA array analysis to identify TFs that were increased or decreased in DNA-binding activity in post-MI hearts. Candidate TFs were identified by combining these two data sets. LV left ventricular, MI myocardial infarction, TFBS transcription factor binding site, DE differentially expressed, TF transcription factor