Current smokers were the reference category, and the horizontal dashed line refers to hazard ratio in never smokers. The multivariate model was adjusted for baseline characteristics, including body-mass index, exercise, alcohol intake, history of diabetes, history of hypertension, history of high cholesterol, parental history of MI prior to 60 years, aspirin treatment, beta-carotene treatment, packs of cigarettes per day, age at started smoking, and age at 60-month questionnaire return. Smoking-related cancers include larynx, kidney, acute myeloid leukemia, oral cavity, esophageal, pancreatic, bladder and stomach cancer.