Table 2.
Association between estimated cytokine factor scores and preterm birth (n=497)
| Cytokine factor | Term n (%) | Preterm n (%) | Unadjusted a preterm birth OR (95% CI) | Adjusted b preterm birth OR (95% CI) |
|---|---|---|---|---|
| Factor 1: Pro-inflammatory / immunomodulatory | ||||
| Tertile 1 (lowest) | 145 (90.6) | 15 (9.4) | 1.0 (ref) | 1.0 (ref) |
| Tertile 2 | 145 (86.3) | 23 (13.7) | 1.5 (0.7, 2.9) | 1.5 (0.7, 2.9) |
| Tertile 3 (highest) | 148 (87.6) | 21 (12.4) | 1.3 (0.6, 2.6) | 1.4 (0.6, 2.6) |
| Factor 2: Anti-inflammatory | ||||
| Tertile 1 (lowest) | 145 (91.9) | 14 (8.8) | 1.0 (ref) | 1.0 (ref) |
| Tertile 2 | 153 (87.9) | 21 (12.1) | 1.4 (0.7, 2.9) | 1.4 (0.7, 2.9) |
| Tertile 3 (highest) | 140 (85.4) | 24 (14.6) | 1.7 (0.8, 3.4) | 1.7 (0.8, 3.4) |
CI, confidence interval; OR, odds ratio
a
Models include only estimated Factor 1 and Factor 2 scores, without adjustment for covariates.
b
Models include Factor 1 scores, Factor 2 scores, and sexually transmitted infections. Adjustment for additional covariates had no meaningful impact any of the findings.