Table 3.
Association between estimated cytokine factor scores and spontaneous preterm birth (n=480)
| Cytokine factor | Term n (%) | sPTB n (%) | Unadjusted a sPTB OR (95% CI) | Adjusted b sPTB OR (95% CI) |
|---|---|---|---|---|
| Factor 1: Pro-inflammatory / immunomodulatory | ||||
| Tertile 1 (lowest) | 145 (94.2) | 9 (5.8) | 1.0 (ref) | 1.0 (ref) |
| Tertile 2 | 145 (90.1) | 16 (9.9) | 1.6 (0.7, 3.8) | 1.6 (0.7, 3.8) |
| Tertile 3 (highest) | 148 (89.7) | 17 (10.3) | 1.7 (0.7, 3.9) | 1.7 (0.7, 3.9) |
| Factor 2: Anti-inflammatory | ||||
| Tertile 1 (lowest) | 145 (94.8) | 8 (5.2) | 1.0 (ref) | 1.0 (ref) |
| Tertile 2 | 153 (91.6) | 14 (8.4) | 1.6 (0.7, 4.0) | 1.6 (0.7, 4.0) |
| Tertile 3 (highest) | 140 (87.5) | 20 (12.5) | 2.4 (1.1, 5.7) | 2.4 (1.1, 5.7) |
CI, confidence interval; OR, odds ratio; sPTB, spontaneous preterm birth
a
.Models include only estimated Factor 1 and Factor 2 scores, without adjustment for covariates.
b
Models include Factor 1 scores, Factor 2 scores, and sexually transmitted infections. Adjustment for additional covariates had no meaningful impact any of the findings.