Table 2.

Substrate Scope of Silver-Mediated Trifluoromethylation^[a][b]

entry	substrate	major product	yield (%)	isomer ratio
1[c]			87	---
2			81	a : b : c 2.7 : 1.4 : 1
3			76	---
4			76	a : b : c 5.2 : 3.5 : 1
5			65	a : b 1.4 : 1
6			78	---
7			87	a : b : c 2.7 : 1.2 : 1
8[c]			88	---
9			85	a : b : c 13 : 7.3 : 1
10			70	a : b 4 : 1
11[c]			46	a : b : c 1.7 : 1.2 : 1
12[c]			44	a : b >20 : 1
13			72	a : b 8 : 1
14[d]			70	a : b 4.8 : 1
15[d]			42	---

^[a]General conditions: substrate (10 equiv), TMSCF₃ (1 equiv) in DCE at 85 °C for 24 h.

^[b]Yield and selectivity determined by ¹⁹F NMR analysis of the crude reaction mixtures.

^[c]20 equiv substrate used.

^[d]5 equiv substrate used.