Table 1.
Frequency of lung cancer risk polymorphisms among healthy Mexican Mestizos.
| Gene (rs) | Genotype frequency, n (%) | Allelic frequency | |||||
|---|---|---|---|---|---|---|---|
| Mutant allele | n | Wild type homozygous | Heterozygous | Mutant homozygous | pb | qc | |
| Ahr (2066853) | Lys | 370 | 260 (70.2) | 107 (29) | 3 (0.8) | 0.85 | 0.15 |
| CYP1A1 (4646903) | C | 382 | 97 (25.4) | 193 (50.5) | 92 (24.1) | 0.51 | 0.49 |
| CYP1A1 (1048943) | Val | 382 | 86 (22.5) | 176 (46.1) | 120 (31.4) | 0.45 | 0.55 |
| CYP1A1 (1800031) | C | 382 | 378 (99) | 4 (1) | 0 | 0.994 | 0.006 |
| CYP1A1 (1799814) | Asn | 382 | 339 (88.7) | 39 (10.3) | 4 (1) | 0.946 | 0.054 |
| CYP2E1 (2031920) | T | 382 | 272 (71.2) | 102 (26.7) | 8 (2.1) | 0.85 | 0.15 |
| EPHX1 (1051740) | His | 382 | 121 (31.7) | 133 (34.8) | 128 (33.5) | 0.49 | 0.51 |
| EPHX1 (2234922) | Arg | 382 | 323 (84.6) | 55 (14.4) | 4 (1) | 0.92 | 0.08 |
| GSTPI (947894) | Val | 382 | 102 (26.7) | 192 (50.3) | 88 (23) | 0.52 | 0.48 |
| GSTM1 (deletion) | Null | 382 | 239 (62.6) | NDa | 143 (37.4) | 0.63 | 0.37 |
| GSTT1 (deletion) | Null | 382 | 324 (84.8) | NDa | 58 (15.2) | 0.85 | 0.15 |
| XRCC1 (25487) | Gln | 382 | 211 (55.2) | 147 (38.5) | 24 (6.3) | 0.75 | 0.25 |
| ERCC2 (13181) | Gln | 382 | 258 (67.5) | 98 (25.7) | 26 (6.8) | 0.8 | 0.2 |
| MGMT (12917) | Phe | 382 | 205 (53.7) | 125 (32.7) | 52 (13.6) | 0.7 | 0.3 |
| CCND1 (603965) | A | 382 | 162 (42.4) | 156 (40.8) | 64 (16.8) | 0.63 | 0.37 |
| TP53 (1042522) | Pro | 382 | 163 (42.7) | 159 (41.6) | 60 (15.7) | 0.64 | 0.36 |
a
Not determined.
b
p – wild type allele.
c
q – mutant allele.