Table 2.

Other neuronal and glial genes differentially expressed in postmortem brains of SCZ and BPD patients and the corresponding genetic mouse models.

Subgroup	Gene	References	Mouse models	Positive findings	References
Schizophrenia: decreased
Myelin proteins	2',3'-cyclic nucleotide 3' phosphodiesterase (CNP)	(Hakak et al., 2001) (McCullumsmith et al., 2007) (Dracheva et al., 2006)	Cnp KO	Compromised axonal survival	(Lappe-Siefke et al., 2003)
Neurogenesis	Neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)	(Bowden et al., 2008) (Altar et al., 2005)
Neuron development	Sema domain, seven thrombospondin repeats (type 1 and type 1- like), transmembrane domain and short cytoplasmic domain, (semaphorin) 5A (SEMA5A)	(Altar et al., 2005)
	Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1)	(Vawter et al., 2001) (Altar et al., 2005)
Schizophrenia: increased
Neuron development	Sema domain, seven thrombospondin repeats (type 1 and type 1- like), transmembrane domain and short cytoplasmic domain, (semaphorin) 5A (SEMA5A)	(Bowden et al., 2008)
Schizophrenia and bipolar: decreased
Myelin proteins	Claudin 11 (CLDN11)	(Dracheva et al., 2006) (Tkachev et al., 2003)	OSP/claudin-11 KO	Tight junctions missing in CNS myelin, slowed conduction, hindlimb weakness	(Gow et al., 1999)
	Myelin associated glycoprotein (MAG)	(Hakak et al., 2001) (Aston et al., 2004) (Dracheva et al., 2006) (McCullumsmith et al., 2007) (Tkachev et al., 2003)	MAG KO	Motor deficits, hyperactive, axon degeneration	(Pan et al., 2005)
	SRY (sex determining region Y)-box 10 (SOX10)	(Dracheva et al., 2006) (Tkachev et al., 2003) (Iwamoto et al., 2005)	SOX10 KO	Die ~birth, no peripheral glia, no terminal differentiation of myelin forming oligodendrocytes	(Britsch et al., 2001), (Stolt et al., 2002)
	Transferrin (TF)	(McCullumsmith et al., 2007) (Hakak et al., 2001) (Arion et al., 2007) (Tkachev et al., 2003)
Neuropeptides	Neuropeptide Y (NPY)	(Kuromitsu et al., 2001)	NPY KO	Anxiogenic in the open field, hypoalgesic	(Bannon et al., 2000)
	Somatostatin (SST)	(Hashimoto et al., 2008) (Hashimoto et al., 2008) (Bowden et al., 2008) (Konradi et al., 2004)	NPY Y2 receptor KO Sst KO	Hyperlocomotion in a novel open field Impaired motor learning	(Karl et al., 2010) (Zeyda et al., 2001)