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Neoamphimedine inhibits Metnase-enhanced TopoIIα-dependent decatenation. (a) A representative TopoIIα-decatenation gel treated with neoamphimedine as indicated; and (b) in the presence of Metnase; (c) Percent inhibition curves generated from decatenation assays in triplicate. DNA markers are denoted as M1 (decatenated, linear and circular) and M2 (catenated).
