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. 2011 Nov 18;9(11):2397–2408. doi: 10.3390/md9112397

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© 2011 by the authors; licensee MDPI, Basel, Switzerland

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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(a) A linear (R² = 0.94) increase in apparent K_m is observed over the range of 0 to 10 μM concentrations of neoamphimedine, indicative of a competitive mode of inhibition; (b) Competitive inhibition studies with ATP depicting a shift in the apparent K_m from 390 ± 50 to 790 ± 120 μM ATP. Using the unpaired, two-tailed t-test analysis, this shift in apparent K_m was statistically significant (P = 0.010) while the V_max for both curves was not (P = 0.186); (c) Dose response curve for the inhibition of TopoIIα ATPase function the IC₅₀ is found to be 2 μM. All data represent means with SEM error bars.