Table 1.
Changes in mitochondrial proteomes in various heart failure studies.
| SPECIES | MODEL | METHODOLOGY | UPREGULATED | DOWN-REGULATED | REFERENCE |
|---|---|---|---|---|---|
| Human | End-stage | 2D-PAGE, LC-MS/MS | Not identified | PDH, VDAC1, Antiox, TCA, ETC | #37 |
| Human | End-stage | 2D-PAGE, PDQUEST | mtCK | MDH | #19, #20 |
| Rat | TAC | Label-free, LC-MS/MS | PDH, TCA, ETC (I, II, V) | FAO, ETC (I, III, IV, V) | #7 |
| Rat | Spontaneously-hypertensive | iTRAQ, MuDPIT MS/MS | Hsp, PDH, Ketone TCA, Apoptosis, Antiox, ETC (I, III, IV) | FAO, ETC (II, V), TCA, mtCK | #17 |
| Rat | Spontaneously-hypertensive | 2D-DIGE, MALDI MS/MS | FAO, TCA, ETC (I, II) | FAO, PDH, ETC (V), VDAC1 | #16, #24 |
| Rat | ACF | 1D-BN-PAGE | --- | ETC (SSM I, III, IV, V) | #36 |
| Dog | DHF, CRT | 2D-DIGE, ESI-MS/MS, BN-PAGE | ETC (, II, III, V), PC, PDH, ADH, Antiox, PHB, VDAC3 | Cyto c, VDAC2 | #2 |
| Rat | Coronary ligation | 2D-PAGE, MALDI-TOF-MS | PDH, TCA | FAO, ETC (I, III, IV, V) | #39 |
| Rabbit | Anthracycline | 2D-DIGE, MALDI-TOF/TOF-MS | ETC (IV, V), PDH | ETC (I), mtCK, VDAC1, ANT1, Antiox | #33 |
| Mouse | Desmin null | 2D-PAGE, MALDI-TOF-MS | Ketone, acetate, ETC (I), VDAC2, Hsp, Ubi1 | Mal/Asp shuttle, Ketone, PDH | #12 |
| Rat | STZ | 2D-PAGE, MALDI-TOF-MS | FAO, Antiox | ETC (I, III) mtCK, VDAC, Hsp | #35 |
| Rat | STZ | 2D-PAGE, MALDI-TOF-MS | FAO, PDH Hsp, ETC (V) |
ETC (I), TCA, ALDH2 | #14 |
| Rat | STZ | iTRAQ, MudPIT MS/MS | FAO, TCA ETC (V) |
ETC (I-V), TCA, mtCK, Hsp, ALDH2, Antiox | #18 |
| Mice | OVE26 | 2D-PAGE, MALDI-TOF-MS | FAO, ETC (V), TCA, PHB | EF-Tu | #32 |
| Mouse | Akita | Label-free, LC-MS/MS | FAO, ETC (V) | TCA, ETC (I, IV) | #6 |
| Mouse | STZ | 2D-DIGE, TRAQ, MudPIT, LC-MALDI TOF/TOF MS |
ETC (SSM: I III, IV, V), TCA (SSM) | FAO, ETC (IFM: I, IV, V), TCA (IFM), Hsp (IFM) | #5 |
| Mouse | Db/db | iTRAQ, LC-MALDI TOF/TOF MS | FAO (SSM, IFM), ETC (IFM: I, III, IV, V), TCA (SSM, IFM) | FAO (IFM), ETC (SSM: I, III, IV V), Hsp (SSM), PRDX5 (SSM) | #10 |
| Mouse | Db/db | 2D-PAGE, LC-ESI-MS/MS, MALDI-TOF/TOF MS | SCOT (Nitration) | --- | #40 |
| Mouse | ALS | 2D-PAGE, MADI-TOF MS | SCOT (Nitration) mtCK (Nitration) PRDX3 (Nitration) |
--- | #34 |
PDH, pyruvatedehydrogenase; VDAC, voltage dependent anion channel; Antiox, antioxidant; TCA, tricarboxylic acid cycle; ETC, electron transport chain; mtCK, mitochondrial creatinekinase; MDH, malatedehydrogenase; FAO, fatty acid oxidation; Hsp, heat shock protein; ADH, aldehydedehydrogenase; PC, pyruvatecarboxylase; Cytoc, cytochromec; ANT, adenine nucleotide translocator; Ubi1, ubiquitin-like 1; ALDH, aldehydedehydrogenase; PHB, prohibitin; EF-Tu, Elongation factor Tu; SCOT, succinyl-CoA:3-oxoacid CoA transferase; PRDX, peroxiredoxin; SSM, subsarcolemmal mitochondria; IFM, interfibrillar mitochondria.