Table 1.

Associations between CRP tagSNPs and colon and rectal cancer risk

CRP genotype1	MAF2	Colon cancer					Rectal cancer
		n Controls	n Cases	OR3	(95%CI)	p4	n Controls	n Cases	OR3	(95%CI)	p4
rs1205 (3’ UTR)	0.32
GG		882	700	1	Referent		406	295	1	Referent
GA		845	659	1.0	(0.9, 1.1)		403	325	1.1	(0.9, 1.4)
AA		157	163	1.3	(1.04, 1.7)	0.12	92	79	1.2	(0.8, 1.7)	0.24
AA vs. GG/GA				1.3	(1.1, 1.7)	0.02			1.1	(0.8, 1.6)	0.47
rs1417938 (intron)	0.30
TT		901	758	1	Referent		472	362	1	Referent
TA		810	629	0.9	(0.8, 1.1)		365	289	1.0	(0.8, 1.3)
AA		172	133	1.0	(0.7, 1.2)	0.49	66	53	1.0	(0.7, 1.5)	0.75
TA/AA vs. TT				0.9	(0.8, 1.1)	0.43			1.0	(0.8, 1.3)	0.74
rs1800947 (L184L)	0.06
GG		1687	1356	1	Referent		786	626	1	Referent
GC		198	161	1.0	(0.8, 1.3)		115	76	0.9	(0.6, 1.2)
CC		2	6	3.2	(0.6, 16.7)	0.48	2	3	1.9	(0.3, 11.3)	0.45
CC/GC vs. GG				1.1	(0.8, 1.3)	0.62			0.9	(0.6, 1.2)	0.37
rs3093075 (3’ flank.)	0.06
CC		1621	1315	1	Referent		771	631	1	Referent
CA		240	198	1.0	(0.8, 1.2)		122	69	0.7	(0.5, 0.9)
AA		14	10	0.8	(0.3, 1.8)	0.68	8	5	0.7	(0.2, 2.1)	0.01
CA/AA vs. CC				1.0	(0.8, 1.2)	0.76			0.7	(0.5, 0.9)	0.01

Abbreviations: tagSNP, tagging single nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio; 95%CI, 95% confidence interval.

¹Recessive model is shown where indicated; dominant is model shown where indicated and for MAFs<0.10; both in bolded font.

²Minor allele frequency in combined colon and rectal study controls, non-Hispanic whites.

³Adjusted for age, sex, race, study center, BMI, recent aspirin/NSAID use, cigarette smoking status, and first-degree family history of colorectal cancer.

⁴P for linear trend used in additive models; p for association used in dominant or recessive models.