Table 2.
Associations between CRP tagSNPs and colon and rectal tumor markers
| Colon tumors: CRP genotype1,2 |
TP53 Mutation
|
KRAS2 Mutation
|
CIMP+
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | OR3 | (95% CI) | p4 | n | OR3 | (95% CI) | p4 | n | OR3 | (95% CI) | p4 | |
| rs1205 (3’ UTR) | ||||||||||||
| GG | 229 | 1 | Referent | 162 | 1 | Referent | 117 | 1 | Referent | |||
| GA | 221 | 1.0 | (0.9, 1.2) | 135 | 0.9 | (0.7, 1.1) | 118 | 1.1 | (0.9, 1.4) | |||
| AA | 54 | 1.1 | (0.8, 1.5) | 0.28 | 46 | 1.4 | (1.0, 1.9) | 0.27 | 33 | 1.3 | (0.9, 1.9) | 0.17 |
| AA vs. GG/GA | 1.1 | (0.8, 1.5) | 0.12 | 297 | 1.5 | (1.1, 2.0) | <0.01 | 235 | 1.3 | (0.9, 1.8) | 0.06 | |
| rs1417938 (intron) | ||||||||||||
| TT | 256 | 1 | Referent | 168 | 1 | Referent | 135 | 1 | Referent | |||
| TA/AA | 248 | 0.9 | (0.8, 1.1) | 0.36 | 176 | 1.0 | (0.8, 1.2) | 0.92 | 133 | 1.0 | (0.8, 1.2) | 0.78 |
| rs3093075 (3’ flank.) | ||||||||||||
| CC | 436 | 1 | Referent | 303 | 1 | Referent | 240 | 1 | Referent | |||
| CA/AA | 70 | 1.0 | (0.8, 1.3) | 0.98 | 40 | 0.8 | (0.6, 1.1) | 0.20 | 28 | 0.7 | (0.5, 1.1) | 0.12 |
|
| ||||||||||||
|
Rectal tumors: CRP genotype1,2 |
TP53 Mutation
|
KRAS2 Mutation
|
CIMP+
|
|||||||||
| n | OR3 | (95% CI) | p4 | n | OR3 | (95% CI) | p4 | n | OR3 | (95% CI) | p4 | |
|
| ||||||||||||
| rs1205 (3’ UTR) | ||||||||||||
| GG | 102 | 1 | Referent | 77 | 1 | Referent | 16 | 1 | Referent | |||
| GA | 126 | 1.2 | (0.9, 1.6) | 65 | 0.8 | (0.6, 1.1) | 28 | 1.7 | (0.9, 3.2) | |||
| AA | 30 | 1.2 | (0.8, 1.9) | 0.12 | 19 | 1.0 | (0.6, 1.7) | 0.85 | 10 | 2.5 | (1.2, 5.3) | 0.01 |
| AA vs. GG/GA | 1.1 | (0.8, 1.5) | 0.45 | 1.1 | (0.7, 1.8) | 0.53 | 1.8 | (1.0, 3.5) | 0.10 | |||
| rs1417938 (intron) | ||||||||||||
| TT | 132 | 1 | Referent | 75 | 1 | Referent | 37 | 1 | Referent | |||
| TA/AA | 128 | 1.1 | (0.8, 1.4) | 0.72 | 87 | 1.3 | (1.0, 1.8) | 0.14 | 17 | 0.5 | (0.3, 0.9) | 0.02 |
| rs3093075 (3’ flank.) | ||||||||||||
| CC | 236 | 1 | Referent | 149 | 1 | Referent | 50 | 1 | Referent | |||
| CA/AA | 25 | 0.7 | (0.4, 1.0) | 0.02 | 14 | 0.6 | (0.3, 0.97) | 0.02 | 4 | 0.6 | (0.2, 1.5) | 0.14 |
Abbreviations: tagSNP, tagging single nucleotide polymorphism; OR, odds ratio; 95%CI, 95% confidence interval.
1
Recessive model is shown where indicated; dominant is model shown where indicated and for MAFs<0.10; both in bolded font.
2
Minor allele frequency in combined colon and rectal study controls, non-Hispanic whites.
3
Adjusted for age, sex, race, study center, BMI, recent aspirin/NSAID use, cigarette smoking status, and first-degree family history of colorectal cancer.
4
P for linear trend used in additive models; p for association used in dominant or recessive models.