Table 3.
Interaction between CRP rs1800947 and body mass index in modifying colon or rectal cancer risk.
| Colon cancer: Genotype1 |
BMI <25
|
BMI 25-30
|
BMI ≥30
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n ctrl. | n case | OR2 | (95% CI) | n ctrl. | n case | OR2 | (95% CI) | n ctrl. | n case | OR2 | (95% CI) | p3 | |
| rs1800947 (L184L) | |||||||||||||
| GG | 654 | 429 | 1 | Referent | 696 | 559 | 1.3 | (1.1, 1.5) | 337 | 368 | 1.8 | (1.4, 2.1) | |
| GC/CC | 79 | 70 | 1.4 | (1.01, 2.0) | 80 | 62 | 1.2 | (0.8, 1.7) | 41 | 35 | 1.3 | (0.8, 2.1) | 0.02 |
|
| |||||||||||||
|
Rectal cancer: Genotype1 |
BMI <25
|
BMI 25-30
|
BMI ≥30
|
||||||||||
| n ctrl. | n case | OR2 | (95% CI) | n ctrl. | n case | OR2 | (95% CI) | n ctrl. | n case | OR2 | (95% CI) | p3 | |
|
| |||||||||||||
| rs1800947 (L184L) | |||||||||||||
| GG | 254 | 212 | 1 | Referent | 337 | 254 | 0.9 | (0.7, 1.2) | 196 | 161 | 1.0 | (0.8, 1.3) | |
| GC/CC | 42 | 19 | 0.5 | (0.3, 0.9) | 51 | 33 | 0.8 | (0.5, 1.3) | 24 | 27 | 1.5 | (0.8, 2.7) | 0.01 |
Abbreviations: tagSNP, tagging single nucleotide polymorphism; OR, odds ratio; 95%CI, 95% confidence interval; ctrl., controls.
1
Dominant is shown due to small numbers of subjects with homozygous CC genotypes.
2
Adjusted for age, sex, race, study center, recent aspirin/NSAID use, cigarette smoking status, and first-degree family history of colorectal cancer.
3
P for multiplicative interaction based on likelihood ratio test (see Methods).