Table 5.
Survival following a diagnosis of colon or rectal cancer in relation to CRP tagSNPs.
| CRP genotype1 | Colon cancer
|
Rectal cancer
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CRC deaths
|
All causes
|
CRC deaths
|
All causes
|
|||||||
| n | HRR2 | (95%CI) | HRR2 | (95%CI) | n | HRR2 | (95%CI) | HRR2 | (95%CI) | |
| rs1205 (3’ UTR) | ||||||||||
| GG | 628 | 1 | Referent | 1 | Referent | 293 | 1 | Referent | 1 | Referent |
| GA | 579 | 1.1 | (0.8, 1.4) | 1.1 | (0.9, 1.1) | 323 | 1.0 | (0.7, 1.5) | 0.8 | (0.6, 1.0) |
| AA | 153 | 0.7 | (0.4, 1.1) | 0.9 | (0.7, 1.0) | 75 | 1.1 | (0.6, 2.0) | 0.8 | (0.6, 1.1) |
| AA vs. GG/GA | 0.7 | (0.4, 1.0) | 0.7 | (0.5, 0.98) | 1.1 | (0.7, 1.8) | 1.0 | (0.6, 1.6) | ||
| rs1417938 (intron 1) | ||||||||||
| TT | 674 | 1 | Referent | 1 | Referent | 356 | 1 | Referent | 1 | Referent |
| TA/AA | 684 | 1.1 | (0.9, 1.4) | 1.1 | (0.9, 1.4) | 340 | 0.9 | (0.6, 1.3) | 0.9 | (0.6, 1.2) |
| rs1800947 (L184L) | ||||||||||
| GG | 1210 | 1 | Referent | 1 | Referent | 620 | 1 | Referent | 1 | Referent |
| GC/CC | 152 | 0.9 | (0.6, 1.4) | 0.9 | (0.6, 1.2) | 77 | 1.0 | (0.6, 1.6) | 0.9 | (0.6, 1.4) |
| rs3093075 (3’ flank.) | ||||||||||
| CC | 1179 | 1 | Referent | 1 | Referent | 624 | 1 | Referent | 1 | Referent |
| CA/AA | 182 | 1.1 | (0.7, 1.6) | 1.1 | (0.8, 1.5) | 73 | 0.8 | (0.5, 1.5) | 0.9 | (0.5, 1.5) |
Abbreviations: tagSNP, tagging single nucleotide polymorphism; HRR, hazard rate ratio; 95%CI, 95% confidence interval; CRC, colorectal cancer.
1
Recessive model for rs1205 is shown in bolded font.
2
Based on 5-year survival, CRC and all-cause mortality; adjusted for age, sex, and American Joint Committee on Cancer disease stage at diagnosis.