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. Author manuscript; available in PMC: 2011 Dec 2.
Published in final edited form as: Cancer Cell. 2011 Jan 18;19(1):17–30. doi: 10.1016/j.ccr.2010.12.014

Figure 4. INHIBITION of IDH1 Reduces Histone Demethylase Activities In Vivo.

Figure 4

(A) Inhibition of IDH1 activity increases histone methylation. Specified histone methylation levels in U-87MG cells treated with increasing concentrations of oxalomalate were analyzed by western blotting.

(B and C) Reduction of IDH1 activity activates HOXA genes. HOXA mRNA levels were analyzed by qRT-PCR in U-87MG cells after knocking down IDH1 (C), and treatment of oxalomalate (B). Error bars represent ± SD for triplicate experiments. See also Figure S4.