Table 2.
NG2 (%) | PDGFRα (%) | CD11b (%) | PDGFRβ (%) | ||
---|---|---|---|---|---|
Sham | WT | 6.12 ± 1.7c | 8.32 ± 2.1c | - | 6.62 ± 0.9c |
KO | - | 6.77 ± 2.6c | - | 4.82 ± 1.4c | |
1W | WT | 100 ± 8.2 | 100 ± 11.5 | 100 ± 9.1 | 100 ± 17.7 |
KO | - | 72.69 ± 16.8* | 33.23 ± 10.3*** | 60.59 ± 15* | |
2W | WT | 75.45 ± 6b | 111.4 ± 1.9 | 174.83 ± 18.6c | 121.71 ± 18.7 |
KO | - | 89.7 ± 6.6*** | 103.13 ± 16.6c** | 87.71 ± 12.4a* | |
6W | WT | 23.99 ± 11.7c | 33.01 ± 4.9c | 6.41 ± 0.8c | 33.83 ± 2.6c |
KO | - | 40.8 ± 6.4a | 4.21 ± 1.3c* | 44.69 ± 7* |
The abundance of various cell types (NG2+, PDGFRα+, CD11b+, PDGFRβ+) in demyelinated lesions from 1-6 weeks post-lysolecithin injection is illustrated by normalizing cell density values to cell densities found in wild type mice at 1 week post-surgery (these 1 week values are designated as 100%). Values represent means ± S.D. Statistically significant differences are indicated by * < 0.05; ** < 0.01; *** < 0.001 when values were compared between WT and NG2 null mice at the same post-injection week. a < 0.05; b < 0.01; c < 0.001 represent statistically significant differences between values obtained for mice of the same genotype when compared to the 1st week post-injection.