Table 4. Odds ratios and related allele frequencies needed to obtain AUCs of 0.70–0.85 in addition to the 53 statistically significant genetic susceptibility variants (AUC = 0.69).

Risk allele Frequency	Number of extra genetic variants	AUC 0.70	AUC 0.75	AUC 0.80	AUC 0.85
0.05	1	1.2	2.3	5.1	9.0
	5	1.2	1.7	2.6	3.6
	20	1.1	1.4	1.7	2.1
	50	1.1	1.2	1.4	1.6
	100	1.1	1.2	1.3	1.4
0.30	1	1.2	1.9	3.0	4.9
	5	1.2	1.4	1.8	2.2
	20	1.1	1.3	1.4	1.6
	50	1.1	1.2	1.3	1.4
	100	1.1	1.2	1.3	1.4
0.50	1	1.2	1.8	3.2	5.3
	5	1.2	1.4	1.8	2.1
	20	1.1	1.3	1.4	1.5
	50	1.1	1.2	1.3	1.4
	100	1.1	1.2	1.3	1.4

NOTE: Odds ratios are presented as mean of 20 simulations each.

AUC: area under the receiver operating characteristic curve.