Table 3. Model Parameter Values: Quality Weights and Cost.

	Base	Min	Max	Source
Quality (utilities) a				[10], [30], [31], [32], [33]
Mild chronic HCV (F0, F1)	0.98	0.70	1.00
SVR following mild HCV	1.00	0.74	1.00
Moderate chronic HCV (F2, F3)	0.85	0.66	1.00
SVR following moderate HCV	0.93	0.71	1.00
Compensated cirrhosis (F4)	0.79	0.46	1.00
SVR following F4	0.93	0.60	1.00
Decompensated cirrhosis	0.72	0.26	0.91
HCC	0.72	0.15	0.95
Liver transplantb	0.81	0.64	1.00
Liver biopsy decrementc	−0.05	−0.20	0	Assumed
Treatment decrement (standard treatment)c	−0.11	−0.20	0
Treatment decrement (triple therapy)c	−0.055	−0.11	0	Assumed
Cost (2009 USD)
Screening test
Liver biopsy	$1,415	$974	$1,623	[8], [34]
FibroTest (FibroSure)	$236	$100	$295	[8]
Treatment (peginterferon and ribavirin + medical care)				[10], [35], [38], [41]
No EVR, genotype 1 (12 weeks)	$7,383	$5,605	$9,020
SVR, genotype 1 (48 weeks)	$29,530	$22,420	$36,080
SVR, genotype 2 and 3 (24 weeks)	$14,765	$11,812	$22,950
Treatment (telaprevir drug cost for 12 weeks)	$49,200	$36,828	$59,040	[39], [53]
Cost of annual cared				[10], [38], [40], [41], [42]
HCV no fibrosis (F0)	$1,610	$150	$2,000
HCV portal fibrosis (F1, F2)	$1,610	$150	$2,000
HCV bridging fibrosis (F3)	$1,610	$150	$2,000
Compensated cirrhosis (F4)	$1,610	$150	$2,000
Decompensated cirrhosis (DC)	$10,930	$5,470	$16,400
HCC	$43,510	$21,760	$65,270
Liver transplant, first year	$143,290	$71,650	$214,930
Liver transplant, subsequent	$25,020	$12,510	$37,540

^aThe quality of life weight for a given age and HCV disease state is computed as the product of the utility associated with the HCV disease state and a mean age-specific quality weight obtained from published data [54], [55].

^bAssumed the utility in the post liver transplant state is the same as the utility in F0 state.

^cUnlike other utilities these decrement are short-term—only the time period when the intervention occurs.

^dBaseline healthcare cost by age is included in the model [56].