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. 2011 Dec 2;6(12):e27474. doi: 10.1371/journal.pone.0027474

Figure 6. Inhibition of PKA binding to AKAPs suppresses the effect of βAR stimulation in TC neurons.

Figure 6

(A) Representative current traces recorded under control conditions (upper left panel) and in the presence of the specific β2AR agonist salmeterol alone (10 µM; left middle panel) or in combination with InCELLect™ AKAP St-Ht31 inhibitory peptide (10 µM; lower left panel). (B) The bar graph represents Dinact under different recording conditions (as indicated). The mean value of four cells recorded under control conditions was taken for comparison with four cells recorded under 10 µM salmeterol and nine cells recorded under 10 µM salmeterol plus InCELLect™ AKAP St-Ht31 inhibitory peptide. Data are presented as means ± SEM of several independent experiments. **P<0.01. Significance of salmeterol (n = 4) versus salmeterol plus InCELLect™ AKAP St-Ht31 inhibitory peptide (n = 9) was calculated by Student's t test. The degree of inactivation is given by the normalized current amplitude of the mean postpulse I/V at +10 mV.