Figure 4.

Analysis of the ability of DEC derivatives to increase the level and the accumulation of endogenous β-catenin (β-cat) in the nucleus. Some of the GFP-DEC constructs described in Figure 3 were transfected into CHO cells (A, C, and E), and their ability to elevate the endogenous β-catenin and induce its translocation into the nucleus (B, D, and F) was determined by double fluorescence as described in Figure 3. Bar in (A), 10 μm. The arrows mark the transfected cells. Note that, whereas DEC13 and DEC induced the accumulation of endogenous β-catenin in the nucleus, DEC9 was unable to do so.