Table 1.
Receptor densities
| Measured parameters | Model parameters | |||
|---|---|---|---|---|
| Value | Unit | Value | Unit | |
| VEGFR1 | ||||
| Luminal EC (normal) | 550 | rec/EC | 1.21 × 10-1 | pmol/cm3 tissue |
| Abluminal EC (normal) | 550 | rec/EC | 9.86 × 10-3 | pmol/cm3 tissue |
| Luminal EC (diseased) | 3,750 | rec/EC | 4.38 × 10-4 | pmol/cm3 tissue |
| Abluminal EC (diseased) | 3,750 | rec/EC | 6.54 × 10-2 | pmol/cm3 tissue |
| Myocytes | 0 | rec/myocyte | 0 | pmol/cm3 tissue |
| Tumor cells | 1,100 | rec/tumor cell | 2.81 × 10-1 | pmol/cm3 tissue |
| VEGFR2 | ||||
| Luminal EC (normal) | 350 | rec/EC | 7.70 × 10-2 | pmol/cm3 tissue |
| Abluminal EC (normal) | 350 | rec/EC | 6.28 × 10-3 | pmol/cm3 tissue |
| Luminal EC (diseased) | 300 | rec/EC | 3.51 × 10-5 | pmol/cm3 tissue |
| Abluminal EC (diseased) | 300 | rec/EC | 5.23 × 10-3 | pmol/cm3 tissue |
| Myocytes | 0 | rec/myocyte | 0 | pmol/cm3 tissue |
| Tumor cells | 550 | rec/tumor cell | 1.41 × 10-1 | pmol/cm3 tissue |
| NRP1 | ||||
| Luminal EC (normal) | 17,500 | rec/EC | 3.74 | pmol/cm3 tissue |
| Abluminal EC (normal) | 17,500 | rec/EC | 3.05 × 10-1 | pmol/cm3 tissue |
| Luminal EC (diseased) | 20,000† | rec/EC | 2.34 × 10-3 | pmol/cm3 tissue |
| Abluminal EC (diseased) | 20,000† | rec/EC | 3.49 × 10-1 | pmol/cm3 tissue |
| Myocytes | 34,500 | rec/myocyte | 2.06 | pmol/cm3 tissue |
| Tumor cells | 39,500 | rec/tumor cell | 1.01 × 101 | pmol/cm3 tissue |
| NRP2 | ||||
| Luminal EC (normal) | 0 | rec/EC | 0 | pmol/cm3 tissue |
| Abluminal EC (normal) | 0 | rec/EC | 0 | pmol/cm3 tissue |
| Luminal EC (diseased) | 0 | rec/EC | 0 | pmol/cm3 tissue |
| Abluminal EC (diseased) | 0 | rec/EC | 0 | pmol/cm3 tissue |
| Myocytes | 0 | rec/myocyte | 0 | pmol/cm3 tissue |
| Tumor cells | 39,500‡ | rec/tumor cell | 1.02 × 101 | pmol/cm3 tissue |
EC = endothelial cell; rec = receptors
† Extrapolated from receptor density on normal ECs, accounting for different cell surface areas
‡No NRP2 quantification available; assumed to be the same as NRP1 on tumor cells
Conversions of receptor densities to tissue concentrations:
Abluminal EC receptors (normal): 1.79 × 10-5 (pmol/cm3 tissue)/(rec/EC);
Luminal EC receptors (normal): 2.20 × 10-4 (pmol/cm3 tissue)/(rec/EC);
Abluminal EC receptors (diseased): 1.74 × 10-5 (pmol/cm3 tissue)/(rec/EC);
Luminal EC receptors (diseased): 1.17 × 10-7 (pmol/cm3 tissue)/(rec/EC);
Myocyte receptors: 5.96 × 10-5 (pmol/cm3 tissue)/(rec/myocyte);
Tumor receptors: 2.55 × 10-4 (pmol/cm3 tissue)/(rec/tumor cell);
Myocyte receptor densities are expressed per myonuclear domain