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. 2011 Dec 2;6(12):e28356. doi: 10.1371/journal.pone.0028356

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Terrile et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Hierarchical clustering (n = 440) of mouse samples. Cluster “Adrenals” contains all the adrenals, while all the tumors samples fall into the cluster “Tumors” The overall miRNAs profile did not resolve the TH-MYCN (green) and TH-MYCN/p53ER^TAM (blue) tumors, or the adrenals derived from wild type (black), TH-MYCN (brown) and TH-MYCN/p53ER^TAM (yellow). (B)–(C). Expression of miR-125b-3p and miR-676 in TH-MYCN (n = 9) and TH-MYCN/p53ER^TAM tumors (n = 13). The miRNAs are significantly down-regulated in the tumors lacking half of the active p53 protein, after Bonferroni multiple comparison correction (respectively p<0.01 and p<0.03).