Table 2. Mortality rates, mean viral loads.
#‡ | Animals infected experimentally | Animals exposed | ||||||||||
Sp* | FR* | MDT* | MVL* † (no. RNA copies) | Sp* | FR* | MDT* | MVL* † (no. RNA copies) | |||||
Swab | Feather | Organ | Swab | Feather | Organ | |||||||
A.1 | SPR | 100 | 4.1 | 2.74×108 | 1.13×1010 | 6.01×1010 | SPR | 0 | NA | 0 | 0 | 0 |
A.2 | SPR | 100 | 3.7 | 2.89×106 | 1.56×106 | 3.37×109 | SPR | 0 | NA | 0 | 0 | 0 |
B.1 | SPR | 100 | 4 | 6.42×105 | 4.34×106 | 1.88×109 | CK | 0 | NA | 0 | 0 | 0 |
B.2 | SPR | 80 | 4 | 1.24×107 | 8.12×102 | 6.37×109 | CK | 100 | 6.5 | 1.87×107 | 1.10×108 | 1.44×1010 |
B.3 | CK | 100 | 2 | 1.35×107 | 3.16×109 | 3.30×109 | NA | NA | NA | NA | NA | NA |
B.4 | NA | NA | NA | NA | NA | NA | CK | 0 | NA | 0 | 0 | 0 |
C | DK | 85 | 3.7 | 8.15×106 | 2.35×1010 | 1.74×1010 | SPR | 50 | 9 | 1.93×106 | 2.59×108 | 5.44×109 |
*Sp = Species (CK = Chicken, DK = Duck, SPR = Sparrow); FR = Fatality Rate (%); MDT = Mean Death Time (days); MVL = Mean Viral Load (no. RNA copies) per mL of swab's supernatant (Swabs), per gram of feathers (Feather), per gram of organ (Organ); NA = Not Applicable.
MVL reported here include data recorded from lethally infected birds only.
All values appearing in the # column correspond to the 7 different experimental settings described in Table 1: A = Sparrows' ability to transmit H5N1 virus to each other when freed in the isolator (A.1) or caged (A.2.); B.1 & B.2 = Sparrows' ability to transmit H5N1 virus to chickens when freed in the isolator (B.1) or caged (B.2); B.3 & B.4 = Chickens' susceptibility to H5N1 when inoculated with 105.23 EID50, dose determined as representing the total amount of virus shed by 24 infected sparrows during one hour through their feces, through direct inoculation (B.3.) or through exposure to contaminated water (B.4); C = Sparrows' ability to be contaminated through contact with infected ducks.