Table 2. Categories of the 133 features describing single amino acid substitutions.
| Site | Neighborhood | Total | |||
| Sequence distance | Euclidean distance | Topological distance | |||
| Sequence-based | 28 | 16 | - | - | 44 |
| Structure-based | 18 | 12 | 30 | 29 | 89 |
| Total | 46 | 28 | 30 | 29 | 133 |
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