Figure 1.

Functional similarity between VN1203-infected Calu-3 cells and macaques. Differentially expressed genes in each treatment were analyzed for their functional enrichment in GO biological process terms. Treatments (system, virus and time combinations) were clustered together based on the functional enrichment scores for a set of 76 GO terms using hierarchical clustering. A partitioning that results in 5 clusters is illustrated using distinct colors for each of the clusters. Treatments are projected on to the first three coordinates obtained via principal component analysis of the matrix of enrichment scores, and are colored based on their cluster membership. Lines indicate the temporal progression of VN1203 infection in each system. Treatments present in each cluster are listed at right.